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10.2337/dc07-0233 63
Many people feel frustrated when they don't see changes after taking supplements, but often, the issue isn't the ingredientit's the delivery
They just need repeated signals over time
DOI: 10.1111/cob.70070
Furthermore, in the EMPA-REG OUTCOME trial, empagliflozin reduced the risk of both pump failure and sudden deaths (46)
Mechanistically it adds steric and electrostatic bulk at the same end of the molecule the binding proteins engage, deepening the reduction in affinity beyond what the single substitution achieves alone
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